真人视频发牌

真人视频发牌|网上游戏
真人视频发牌|网上游戏
首页» 课题组» 分析化学» 赵美萍
 

赵美萍

教授,博士生导师

研究方向:分析化学

办公室:B333
电话:010-62758153
电子信箱:mpzhao@pku.edu.cn
课题组网站:/mpzhao

学术简历:

  • 2010 –至今   教授,网上真人发牌游戏
  • 2002 –2010   副教授,网上真人发牌游戏
  • 1998.7-1998.11   访问学者 荷兰能源研究机构 环境分析部
  • 1997.9–1998.6   访问学者 荷兰阿姆斯特丹大学 环境与毒理化学系
  • 2002   理学博士 真人视频发牌 网上真人发牌游戏
  • 1993   理学硕士 真人视频发牌 环境科学中心
  • 1990   理学学士 真人视频发牌 技术物理系

研究领域和兴趣:

本课题组致力于探索和构建新颖的分子识别体系,发展实时、在线的荧光分析方法,为生命科学研究、临床检验、环境监测和食品安全监控提供高效的分析测量手段。目前的主要研究方向:
  1. 细胞内核酸修复酶的荧光成像方法;
  2. 低丰度基因突变的超高灵敏检测及其在临床检验中的应用;
  3. 新型功能化分子识别新材料的设计、合成和应用;
  4. 外源基因的识别和定位方法。

代表性论文:

  1. JQ Zhai, MH Zhao, XJ Cao, MY Li*, MP Zhao*, Metal-ion-responsive bionanocomposite for selective and reversible enzyme inhibition, Journal of the American Chemical Society, 2018, 140, 16925.
  2. TB Wu, YF Yang, W Chen, JY Wang, ZY Yang, SL Wang, XJ Xiao, MY Li, MP Zhao*, Noncanonical substrate preference of lambda exonuclease for 5'-nonphosphate-ended dsDNA and a mismatch-induced acceleration effect on the enzymatic reaction, Nucleic Acids Research, 2018, 46, 3119.
  3. TB Wu, W Chen, ZY Yang, HC Tan, JY Wang, XJ Xiao, MY Li, MP Zhao*, DNA terminal structure-mediated enzymatic reaction for ultra-sensitive discrimination of single nucleotide variations in circulating cell-free DNA, Nucleic Acids Research, 2018, 46(4), e24.
  4. XJ Xiao, TB Wu, L Xu, W Chen, MP Zhao*, A branch-migration based fluorescent probe for straightforward, sensitive and specific discrimination of DNA mutations, Nucleic Acids Research, 2017, 45 (10): e90.
  5. JQ Zhai, YB Liu, S Huang, SM Fang, MP Zhao*, A specific DNA-nanoprobe for optically tracking the activities of human apurinic/apyrimidinic endonuclease 1 in living cells, Nucleic Acids Research, 2017, 45(6), e45.
  6. XJ Xiao, TB Wu, FD Gu, MP Zhao*, Generation of artificial sequence-specific nucleases via preassembled inert-template, Chemical Science, 2016, 7, 2051.
  7. SM Fang, L Chen, MP Zhao*, Unimolecular chemically modified DNA fluorescent probe for one-step quantitative measurement of the activity of human apurinic/ apyrimidinic endonuclease 1 in biological samples, Analytical Chemistry, 2015, 87, 11952.
  8. XJ Xiao, C Zhang, X Su, C Song, MP Zhao*, A universal mismatch-directed signal amplification platform for ultra-selective and sensitive DNA detection under mild isothermal conditions, Chemical Science, 2012, 3, 2257.
  9. ZY Chen, L Xu, Y Liang, MP Zhao*, pH-Sensitive water-soluble nanospheric imprinted hydrogels prepared as horseradish peroxidase mimetic enzyme, Advanced Materials, 2010, 22, 1488.
  10. C Song, MP Zhao*, Real-time monitoring of the activity and kinetics of T4 polynucleotide kinase by a singly labeled DNA-hairpin smart probe coupled with  exonuclease cleavage, Analytical Chemistry, 2009, 81, 1383.
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